Methamphetamine neurotoxicity, microglia, and neuroinflammation
نویسندگان
چکیده
منابع مشابه
Role of microglia in methamphetamine-induced neurotoxicity.
Methamphetamine (Meth) is an addictive psychostimulant widely abused around the world. The chronic use of Meth produces neurotoxicity featured by dopaminergic terminal damage and microgliosis, resulting in serious neurological and behavioral consequences. Ample evidence indicate that Meth causes microglial activation and resultant secretion of pro-inflammatory molecules leading to neural injury...
متن کاملFeatures of Microglia and Neuroinflammation Relevant to Environmental Exposure and Neurotoxicity
Microglia are resident cells of the brain involved in regulatory processes critical for development, maintenance of the neural environment, injury and repair. They belong to the monocytic-macrophage lineage and serve as brain immune cells to orchestrate innate immune responses; however, they are distinct from other tissue macrophages due to their relatively quiescent phenotype and tight regulat...
متن کاملDiesel Exhaust Activates and Primes Microglia: Air Pollution, Neuroinflammation, and Regulation of Dopaminergic Neurotoxicity
BACKGROUND Air pollution is linked to central nervous system disease, but the mechanisms responsible are poorly understood. OBJECTIVES Here, we sought to address the brain-region-specific effects of diesel exhaust (DE) and key cellular mechanisms underlying DE-induced microglia activation, neuroinflammation, and dopaminergic (DA) neurotoxicity. METHODS Rats were exposed to DE (2.0, 0.5, and...
متن کامل[Microglia in neurodegenerative disorders and neuroinflammation].
Microglia often accumulate around degenerating neurons. These macrophage-like immune cells produce a variety of neurotoxic and neuroprotective factors. Thus, the accumulation of glia in various neurologic disorders does not reflect only gliosis, but likely results in an active contribution to neuroinflammation, neural degeneration, and cell regeneration. We previously showed that glutamate is t...
متن کاملΔ9-Tetrahydrocannabinol Prevents Methamphetamine-Induced Neurotoxicity
Methamphetamine (METH) is a potent psychostimulant with neurotoxic properties. Heavy use increases the activation of neuronal nitric oxide synthase (nNOS), production of peroxynitrites, microglia stimulation, and induces hyperthermia and anorectic effects. Most METH recreational users also consume cannabis. Preclinical studies have shown that natural (Δ9-tetrahydrocannabinol, Δ9-THC) and synthe...
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ژورنال
عنوان ژورنال: Journal of Neuroinflammation
سال: 2018
ISSN: 1742-2094
DOI: 10.1186/s12974-018-1385-0